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目的评价川芎嗪注射液对急性缺血性脑卒中患者血清MMP-9及神经功能缺损的影响。方法回顾性分析民权县中医院2012年11月至2015年1月确诊的124例急性缺血性脑卒中病例,按治疗方式不同平均分为两组。对照组62例,采用西药常规治疗措施;观察组62例,实施西药常规联合川芎嗪注射液治疗,两组疗程均为15d。于治疗前后,分别对比两组患者疗效、神经功能缺损(NIHSS)评分及血清MMP-9水平。结果观察组与对照组的总疗效分别是95.16%、77.42%,组间比较差异有统计学意义(P<0.05);两组患者治疗后MMP-9水平及NIHSS评分较治疗前均显著下降,观察组较对照组下降幅度明显,差异均有统计学意义(P<0.05)。结论川芎嗪注射液治疗急性缺血性脑卒中具有显著疗效高,可明显降低血清MMP-9水平,缓解神经功能缺损。
Objective To evaluate the effect of ligustrazine injection on serum MMP-9 and neurological impairment in patients with acute ischemic stroke. Methods A retrospective analysis of 124 patients with acute ischemic stroke diagnosed by Civil Rights Hospital of TCM from November 2012 to January 2015 was divided into two groups according to the average of different treatment methods. The control group of 62 cases, the conventional treatment of Western medicine; observation group of 62 cases, the implementation of conventional western medicine and ligustrazine injection treatment, both groups were 15d. Before and after treatment, the efficacy, neurological deficit (NIHSS) score and serum MMP-9 level were compared between the two groups. Results The total curative effect of the observation group and the control group was 95.16% and 77.42%, respectively. The difference between the two groups was statistically significant (P <0.05). The MMP-9 level and NIHSS score of the two groups were significantly decreased after treatment, The observation group than the control group decreased significantly, the differences were statistically significant (P <0.05). Conclusion Ligustrazine injection has obvious curative effect in treating acute ischemic stroke, and can significantly decrease serum MMP-9 level and relieve neurological deficit.