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乙酰胆碱是由胆碱能神经释放的扩血管物质,也可来自某些内皮细胞。其作用机理是抑制交感神经释放去甲肾上腺素、刺激内皮细胞释放松弛因子(EDRF)及刺激血管壁产生前列环素。本研究旨在观察乙酰胆碱扩张人体前臂血管的机理,对比观察它对正常人和无并发症的高血压病患者血管作用之差别,并了解高血压病患者是否象高血压动物的离体动脉一样对乙酰胆碱的反应异常。方法单次坐位舒张压小于12.0kPa 的健康志愿者20例(男12,女8,年龄20～73
Acetylcholine is released from the cholinergic nerve vasodilator substances, but also from some endothelial cells. Its mechanism of action is to inhibit the sympathetic release of norepinephrine, stimulate the release of endothelial cell relaxing factor (EDRF) and stimulate the vascular wall to produce prostacyclin. The purpose of this study was to investigate the mechanism of acetylcholine dilation of forearm blood vessels in humans and to compare the effects of acetylcholine on blood vessels in normal and uncomplicated hypertensive patients and to understand whether hypertensive patients are like the isolated arteries of hypertensive animals Acetylcholine reaction abnormalities. Methods 20 healthy volunteers with a single sitting diastolic pressure less than 12.0 kPa (male 12, female 8, age 20-73