A rapid absorbance-based growth assay to screen the toxicity of oligomer Aβ42 and protect against ce

• 作 者: Prashant Bharadwaj Ralph Marti
• 机 构: CentreofExcellenceforAlzheimer’sDiseaseResearchandCare,SchoolofPharmacyandBiomedicalSciences,Schoolo
• 出 处: 中国神经再生研究:英文版
• 发表日期: 2020年10期
• 关键词: Alzheimer’s disease amyloid TOXICITY autophagy AΒ42 OLIGOMER high-throughput scr
• 基金项目: This study was supported by the National Health and Medical Research Council-Australian Research Council dementia research development fellowship(APP1107109)to PB.

Multiple lines of evidence show that soluble oligomer forms of amyloidβprotein(Aβ42)are the most neurotoxic species in the brain and correlates with the degree of neuronal loss and cognitive deficit in Alzheimer’s disease.Although many studies have used m