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目的:D-聚甘酯是从海藻中提取的一种多糖,其纯度90%以上,分子量3000~5000,为类肝素抗凝剂,主要用于脑卒中急性期的治疗,由于D-聚甘酯是一种新型海洋药物,属一类新药,因此我们对它的致畸性和胚胎毒性进行了研究,以确定D-聚甘酯的安全剂量范围。方法?
Objective: D-polyglycerol is a kind of polysaccharide extracted from seaweed. Its purity is above 90% and its molecular weight is 3000-5000. It is a kind of anticoagulant for heparin. It is mainly used in the treatment of acute stroke. Because D- Ester is a new marine drug, a new class of drugs, so we investigated its teratogenicity and embryotoxicity to determine the safe dose range of D-polyglycerides. method?