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丝虫蛋白酶在虫体发育、蜕皮和体内移行等方面起着关键作用。但人体丝虫感染中丝虫蛋白酶的抗原性未为人知。为了阐明丝虫感染中寄生虫蛋白酶在人体内的免疫学地位,从牛的指状腹腔丝虫(常被用于替代班氏丝虫的抗原)中分离出了两种蛋白水解酶:一种是低分子量的锌依赖性半胱氨酸蛋白酶(Sd30),另一种是高分子量蛋白酶(Sdp_1)。本文作者研究了人体丝虫病中针对该酶产生的IgG亚类及IgG对该蛋白酶活性的影响。
The filarial protease plays a key role in the development of worms, molting and in vivo migration. However, the antigenicity of filarial protease in human filarial infections is unknown. In order to elucidate the immunological status of parasite proteases in filarial infections in humans, two proteolytic enzymes were isolated from bovine finger-shaped, peritoneal filarial, an antigen commonly used to replace Banday filariasis Is a low-molecular-weight zinc-dependent cysteine protease (Sd30) and the other is a high-molecular-weight protease (Sdp_1). The authors investigated the effects of IgG subclasses and IgG on the protease activity of human filariasis in human filariasis.