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目的研究p53抑癌基因和nm23肿瘤转移抑制基因与卵巢上皮性癌的关系。方法采用免疫组化SP法检测12例正常卵巢组织,20例卵巢良性肿瘤,16例交界性肿瘤以及79例卵巢上皮性癌组织中p53及nm23的表达情况。结果p53表达率于卵巢上皮性癌为48.1%,其他组织均呈阴性,与组织类型无关,但与分化程度成反比,与分期、淋巴结转移成正相关。COX模型单因素及多因素分析显示,p53表达与预后相关;nm23表达率于卵巢上皮性癌中为49.3%,且与组织类型、细胞分化,临床分期以及淋巴结转移均有相关性,COX模型单因素分析表明nm23表达与预后有关。结论p53和nm23可作为估计患者预后的指标,前者阳性者预后欠佳,后者阳性者预后较好。
Objective To study the relationship between p53 tumor suppressor gene and nm23 tumor metastasis suppressor gene and epithelial ovarian cancer. Methods The expressions of p53 and nm23 in 12 cases of normal ovarian tissue, 20 cases of ovarian benign tumor, 16 cases of borderline tumor and 79 cases of epithelial ovarian cancer were detected by immunohistochemical SP method. Results The positive expression rate of p53 in epithelial ovarian cancer was 48.1%. Other tissues were negative, but not related to the type of tissue. However, the positive rate of p53 was inversely correlated with the degree of differentiation and positively correlated with the stage and lymph node metastasis. COX model univariate and multivariate analysis showed that p53 expression was correlated with prognosis. The expression rate of nm23 in epithelial ovarian cancer was 49.3%, and correlated with tissue type, cell differentiation, clinical stage and lymph node metastasis. COX model single Factor analysis showed that nm23 expression correlated with prognosis. Conclusions Both p53 and nm23 can be used as predictors of prognosis in patients with positive prognosis. However, patients with positive positivity have a better prognosis.