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一般认为甲状腺功能低下(甲低)病人用甲状腺素(T_4)替代疗法时的剂量是否适当,靠观察临床反应即已足够,也有人测定促甲状腺素(TSH)以观察之。但过量时引起轻度医源性甲状腺功能亢进(甲亢)却不能靠TSH测定来发现,因为许多正常人的血清TSH浓度很低,此时应抽血测定甲状腺素。过去认为抽血时间和服药时间无关,作者进一步研究了口服甲状腺素后的当时血中甲状腺素变化。作者采用了2种服药时间,即短期法和3天法。前者是在服100、150、200或300μg T_4前及后1/2、1、2、4、6小时采血;后者是服T_4200μg/d,用同样方法采3天的血标本。研究对象为5名正常人及11例
Is generally considered hypothyroidism (hypothyroidism) patients with thyroid hormone (T_4) replacement therapy dose is appropriate, by observing the clinical response is sufficient, but also for the determination of thyroid stimulating hormone (TSH) to observe. However, overdose caused by mild iatrogenic hyperthyroidism (hyperthyroidism) can not be detected by TSH to find, because many normal serum TSH concentration is very low, this time blood should be measured thyroxine. In the past that blood drawing time and medication time has nothing to do, the authors further study the thyroxine after thyroid hormone changes in the blood. The authors adopted two kinds of medication time, that is, short-term and 3-day law. The former is taking 100, 150, 200 or 300μg T_4 before and after 1 / 2,1,2,4,6 hours to take blood; the latter is served T_4200μg / d, the same way for 3 days blood samples. The subjects were 5 normal subjects and 11 patients