【摘 要】
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目的:研究宫颈癌中细胞凋亡与放疗和放化疗临床效果的关系.方法:采用免疫组织化学法和脱氧核糖核酸转移酶介导的缺口末端标记(TUNEL)技术,检测60例宫颈癌患者治疗前后宫颈肿
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目的:研究宫颈癌中细胞凋亡与放疗和放化疗临床效果的关系.方法:采用免疫组织化学法和脱氧核糖核酸转移酶介导的缺口末端标记(TUNEL)技术,检测60例宫颈癌患者治疗前后宫颈肿瘤细胞凋亡率.结果:在宫颈癌组织中,单纯放疗(radiotherapy,RT)前和放疗10 Gy后,肿瘤细胞凋亡率分别为33.33%和66.67%,有统计学差异(P＜0.05);放化疗(synchronal radiochemotherapy,CRT)组治疗前和先行一次化疗再放疗10 Gy后,肿瘤细胞凋亡率分别为36.67%和93.33%,两者有统计学差异(P＜0.01).治疗前组间对比阳性率无统计学差异(P＞0.05),治疗后组间对比,放化疗组凋亡阳性率明显高于单纯放疗组,差异有统计学意义(P＜0.05),且细胞凋亡与近期临床疗效呈正相关(r=0.823, P
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