【摘 要】
：
Type 2 diabetes (T2D) is characterized by the malfunction of pancreatic β cells. Susceptibility and patho-genesis of T2D can be affected by multiple factors, including sex differences. However, the mechanisms underlying sex differences in T2D susceptibili
【机 构】
：
Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine,Shanghai
【出 处】
：
基因组蛋白质组与生物信息学报（英文版）
论文部分内容阅读
Type 2 diabetes (T2D) is characterized by the malfunction of pancreatic β cells. Susceptibility and patho-genesis of T2D can be affected by multiple factors, including sex differences. However, the mechanisms underlying sex differences in T2D susceptibility and pathogenesis remain unclear. Using single-cell RNA sequencing (scRNA-seq), we demonstrate the presence of sexually dimorphic transcriptomes in mouse β cells. Using a high-fat diet-induced T2D mouse model, we identified sex-dependent T2D altered genes, suggesting sex-based differences in the pathological mechanisms of T2D. Furthermore, based on islet transplantation experiments, we found that compared to mice with sex-matched islet transplants, sex-mismatched islet transplants in healthy mice showed down-regulation of genes involved in the longevity regulating pathway ofβcells. Moreover, the diabetic mice with sex-mismatched islet transplants showed impaired glucose tolerance. These data suggest sexual dimorphism in T2D pathogenicity, indicating that sex should be considered when treating T2D. We hope that our findings could provide new insights for the development of precision medicine in T2D.
其他文献
为探究团簇Fe3 Ni3优化构型的稳定性及其受外场影响的形变情况,并研究其催化性质,使用密度泛函理论中的B3LYP/Lanl2dz(Level)对设计出的初始构型进行全参数优化计算,将含虚频和能量较高的相同构型排除后,最终得到9种稳定的优化构型.从各优化构型的极化率、前线轨道及福井函数分析发现:构型4(3)的极化率最大,原子间的相互作用力最小,构型易发生形变,且构型4(3)的能隙差最小,电子从HOMO轨道向LUMO轨道转移的难度最小,在催化反应过程中反应活性最好;单重态构型比三重态构型原子间相互作用力更强
基于水劣化足迹的评价方法,对江西省不同工业行业在多个时间和空间维度上排放的污染物进行水富营养化足迹、水酸化足迹和水生态毒性足迹的核算和评价.研究结果表明:(i)2017年,对江西省水富营养化足迹影响最大的关键行业是有色金属冶炼和压延加工业,其次是造纸和纸制品业,再次是化学原料和化学制品制造业,关键污染物是氨氮(NH3-N);对水酸化足迹影响较大的关键行业是非金属矿物制品业与黑色金属冶炼和压延加工业,关键污染物是SO2;对水生态毒性足迹影响最为显著的是有色金属矿采选业,关键污染物是Cd.(ii)空间维度评估
Isogenic cells growing in identical environments show cell-to-cell variations because of the stochasticity in gene expression. High levels of variation or noise can disrupt robust gene expression and result in tremendous consequences for cell behaviors. I
The newly developed technologies for profiling cellular heterogeneity have spurred a world-wide pursuit of single-cell analysis in the field of omics studies, investigating the genome, epigenome, transcriptome, proteome, metabo-lome, and their inherent in
Development of thoracolumbar vertebra (TLV) and rib primordium (RP) is a common evolutionary feature across vertebrates, although whole-organism analysis of the expression dynamics of TLV-and RP-related genes has been lacking. Here, we investigated the si
There is an imbalance between the supply and demand of functional red blood cells (RBCs) in clinical appli-cations. This imbalance can be addressed by regenerating RBCs using several in vitro methods. Induced pluripotent stem cells (iPSCs) can handle the
Single-cell genomics provides substantial resources for dissecting cellular heterogeneity and cancer evolution. Unfortunately, classical DNA amplification-based methods have low throughput and introduce coverage bias during sample preamplification. We dev
基于改进引力模型和PSR模型探究了2008—2018年在生态安全约束下环鄱阳湖生态城市群时空演化格局,通过障碍度模型分析最大障碍因子,结果表明:(i)环鄱阳湖生态城市群整体生态安全处于风险级,地域分异特征明显,形成以鄱阳湖为中心向四周递减的生态安全格局;(ii)生态安全障碍度总体呈减小态势,各个城市最大障碍因子多数集中在压力要素层,且障碍度较高的市辖区的最大障碍因子障碍度普遍偏高,且稳定性最为明显;(iii)经济引力不断增强,但内部差异逐渐增大,呈“向心性”发展,“廊道效应”明显;生态引力呈摊饼式“团块状
Cashmere, also known as soft gold, is produced from the secondary hair follicles (SHFs) of cashmere goats. The number of SHFs determines the yield and quality of cashmere;therefore, it is of interest to investigate the transcriptional profiles present dur
During early embryonic development, cell fate commitment represents a critical transition or“tipping point”of embryonic differentiation, at which there is a drastic and qualitative shift of the cell populations. In this study, we presented a computational