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用血清学方法对胃癌高发区兰州地区３７８１名各年龄组健康人群进行前瞻性幽门螺杆菌（Ｈｅｌｉｃｏｂａｃｔｅｒｐｙｌｏｒｉ，ＨＰ）感染调查，并与胃癌低发区广州地区的资料进行比较。结果显示：兰州地区ＨＰ总感染标化率为６１．６％，高于广州地区的４８．３％（Ｐ＜０．００１）。两者之间的差异在１０岁以下儿童，尤其是４岁以下幼儿最显著（分别为４３．２％与１９．３％，Ｐ＜０．００１）；兰州地区ＨＰ阳性率的高峰年龄段在３０～３９岁，比广州地区提早１０年以上出现，可能与胃癌高发区人群较早出现ＨＰ相关性萎缩性胃炎及肠上皮化生有关。
Serological methods were used to investigate prospective Helicobacter pylori (HP) infection in 3781 healthy people of different age groups in Lanzhou area of high incidence area of gastric cancer, and compared with the data of Guangzhou area with low incidence of gastric cancer. The results showed that the standardized rate of HP infection in Lanzhou was 61.6%, which was higher than 48.3% in Guangzhou (P<0.001). Differences between the two were most pronounced in children under 10 years of age, especially children under 4 years of age (43.2% and 19.3%, respectively, P<0.001); the peak age of HP positive rate in Lanzhou was 30 to 39 years old, appearing more than 10 years earlier than Guangzhou, may be related to HP-related atrophic gastritis and intestinal metaplasia earlier in population with high incidence of gastric cancer.