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哺乳类细胞中磷脂酰肌醇3-激酶家族成员之一共济失调毛细血管扩张症突变基因(ataxia-telangiectasiamutated,ATM)是毛细血管扩张共济失调综合征的致病基因,一种对电离辐射极度敏感的遗传性疾病,具有基因组不稳定性和肿瘤易感性的特征。ATM在细胞周期调控中起重要作用,此基因的变异会导致放射治疗敏感性和肿瘤易感性增加。用人工方法造成类似ATM基因突变状态、抑制ATM基因功能或直接通过下调ATM基因产物的表达来增加患者对放射线的敏感性以提高放射治疗疗效,可能是治疗恶性肿瘤的一个良好策略。本文主要综述ATM基因变异或基因蛋白产物水平与肿瘤对放射线敏感性之间的关系,
Ataxia-telangiectasiamyutase (ATM), a member of the phosphatidylinositol 3-kinase family in mammalian cells, is a causative agent of the telangiectasiasaxis syndrome and one of the mechanisms responsible for ionizing radiation Extremely sensitive genetic disease, with genomic instability and tumor susceptibility characteristics. ATM plays an important role in the regulation of cell cycle. The variation of this gene will lead to the increase of radiotherapy sensitivity and tumor susceptibility. It may be a good strategy to treat malignant tumors by artificially causing similar ATM gene mutation status, inhibiting the function of ATM genes or directly increasing the sensitivity of patients to radiation to decrease the expression of ATM gene products. This article reviews the relationship between ATM gene mutation or gene protein product level and tumor sensitivity to radiation,