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目的:研究乳腺导管内乳头状瘤中是否存在高危型人乳头瘤病毒(HPV)的感染。方法:采用二代杂交捕获技术(HC2)定量检测30例乳腺导管内乳头状瘤患者的肿瘤组织或乳头溢液和18例乳腺纤维腺瘤患者肿瘤组织中13种高危型HPV DNA的含量。结果:30例乳腺导管内乳头状瘤组织或溢液中有3例呈阳性(检测值>1),阳性率为10%,而18例乳腺纤维腺瘤患者肿瘤组织中未发现高危型HPV的感染。30例乳腺导管内乳头状瘤患者中中央型导管内乳头状瘤11例,周围型导管内乳头状瘤19例,3例阳性者均为中央型,中央型导管内乳头状瘤的HPV阳性率与周围型导管内乳头状瘤存在明显差异(P<0.05)。结论:乳腺导管内乳头状瘤存在高危型HPV的感染,HPV感染的来源可能是通过乳管的开口进入乳腺,不能支持高危型HPV感染与乳腺导管内乳头状瘤发展及癌变有关的观点。
Objective: To investigate whether there is high-risk human papillomavirus (HPV) infection in intraductal papilloma. Methods: HC2 was used to detect the content of 13 kinds of high risk HPV DNA in tumor tissue or nipple discharge of 30 cases of breast ductal papilloma and 18 cases of breast fibroadenoma. Results: Of the 30 cases of breast ductal papilloma tissue or discharge in 3 cases were positive (detection value> 1), the positive rate was 10%, while 18 cases of breast fibroadenoma tumor tissue was not found in high-risk HPV infection. In 30 cases of intraductal papilloma, there were 11 cases of central intraductal papilloma, 19 cases of peripheral intraductal papilloma, and 3 cases were positive for central papilloma. The HPV positive rate of central intraductal papilloma And peripheral ductal papilloma were significantly different (P <0.05). CONCLUSIONS: Breast ductal papillomas have high-risk HPV infection. The source of HPV infection may be through the opening of the duct into the breast, and can not support the view that high-risk HPV infection is associated with the development of breast ductal papilloma and canceration.