emerging role of the β-catenin-PPARγ axis in the pathogenesis of colorectal cancer

• 作 者: Lina Sabatino Massimo Pancione
• 机 构: DepartmentofSciencesandTechnologies,DepartmentofPharmacy
• 出 处: 世界胃肠病学杂志：英文版（电子版）
• 发表日期: 2014年23期
• 关键词: Colorectal cancer WNT/Β-CATENIN pathway PEROXISOME Colorectal cancer Wnt/&#
• 基金项目: Ministero dell’Istruzione,Università e Ricerca,MIUR-PRIN 2010-2011,No.prot.2010W7YRLZ_003

Multiple lines of evidence indicate that Wnt/β-catenin signaling plays a fundamental role in colorectal cancer(CRC)initiation and progression.Recent genome-wide data have confirmed that in CRC this pathway is one of the most frequently modified by genetic