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目的 探讨妊娠期病毒性肝炎对围产儿的影响。方法 测定 47名正常孕妇和 495例病毒性肝炎孕妇所生新生儿Apgar评分和出生时体重 ,并检测新生儿血清肝炎病毒标志。 结果 肝炎孕妇所生新生儿Apgar评分和出生时体重均显著低于对照组 (均P <0 .0 1 )。急性肝炎孕妇所生新生儿 1minApgar评分和出生时体重均显著低于乙型肝炎病毒 (HBV)携带和慢性肝炎组 (均P <0 .0 1 )。甲型肝炎未见宫内感染。HBV ,丙型肝炎病毒 (HCV)和戊型肝炎病毒(HEV)宫内感染率分别为 30 .0 % (87/ 2 99) ,1 1 .1 % (1 / 9)和 2 0 .8% (5/ 2 4 )。HBV感染孕妇所生宫内感染和无宫内感染新生儿Apgar评分和出生时体重间均无显著差异 (均P >0 .0 5)。 结论 妊娠期病毒性肝炎对围产儿生长发育和出生时状态有明显影响 ,急性肝炎影响尤大。HBV ,HCV和HEV均存在垂直传播。HAV垂直传播较少见。HBV宫内感染对围产儿生长发育和出生时状态影响不明显
Objective To investigate the influence of viral hepatitis during pregnancy on perinatal children. Methods Apgar score and weight at birth of 47 normal pregnant women and 495 pregnant women with viral hepatitis were measured, and neonatal serum hepatitis virus markers were detected. Results Apgar score and weight at birth of neonates born to hepatitis were significantly lower than those of control group (all P <0.01). The newborn infants born at 1 min and the birth weight of pregnant women with acute hepatitis were significantly lower than those of carriers of hepatitis B and chronic hepatitis (all P <0.01). Hepatitis A no intrauterine infection. The intrauterine infection rates of HBV, Hepatitis C virus (HCV) and Hepatitis E virus (HEV) were 30.0% (87/299), 11.1% (1/9) and 20.8% (5/2 4). There was no significant difference in neonatal Apgar score and birth weight between pregnant women with HBV infection and those without intrauterine infection (all P> 0.05). Conclusions Viral hepatitis in pregnancy has a significant effect on the growth and development of perinatal infants and the status at birth. The acute hepatitis has a particularly serious impact. Vertical transmission occurs in HBV, HCV and HEV. Vertical transmission of HAV is less common. HBV intrauterine infection has no obvious effect on the growth and development of perinatal infants and the status at birth