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目的探讨抗甲状腺过氧化物酶抗体(TPOAb)和抗促甲状腺素受体抗体(TRAb)在Graves病中的诊断价值。方法将甲状腺疾病患者根据其临床诊断将其分为Graves病组(n=105)、桥本病组(n=66)、甲亢型亚甲炎组(n=29);另选择同期健康体检者作为对照组(n=59)。分别采用电化学发光法和化学发光法检测其血清TRAb和TPOAb水平,并对其中46例Graves病患者血清TRAb和TPOAb进行动态监测。结果与桥本病组比较,Graves病组患者血清TRAb水平及阳性率较高(P<0.05),而其TPOAb水平及阳性率较低(P<0.05)。治疗有效的Graves病患者,血清TRAb水平随症状的缓解而逐渐下降。血清TPOAb水平与治疗有效与否关系不大。结论 TRAb和TPOAb检测在Graves病的诊断及鉴别诊断中具有重要意义,TRAb的动态监测有助于临床疗效的判断。
Objective To investigate the diagnostic value of anti-thyroid peroxidase antibody (TPOAb) and anti-thyrotropin receptor antibody (TRAb) in Graves disease. Methods Patients with thyroid disease were divided into Graves’ disease group (n = 105), Hashimoto’s disease group (n = 66) and hyperthyroidism type (n = 29) according to their clinical diagnosis. As a control group (n = 59). The serum levels of TRAb and TPOAb were detected by chemiluminescence and chemiluminescence respectively. The serum levels of TRAb and TPOAb in 46 patients with Graves’ disease were monitored dynamically. Results Compared with Hashimoto disease group, serum TRAb level and positive rate in patients with Graves’ disease were higher (P <0.05), while the level of TPOAb and the positive rate were lower (P <0.05). Treated patients with Graves disease, serum TRAb levels gradually decreased with the relief of symptoms. Serum TPOAb levels and the effectiveness of treatment or not. Conclusion The detection of TRAb and TPOAb is of great significance in the diagnosis and differential diagnosis of Graves’ disease. The dynamic monitoring of TRAb is helpful to the judgment of clinical efficacy.