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肿瘤的抗血管生成疗法是通过肿瘤内新生血管的形成来抑制肿瘤的生长和转移。内皮抑素是当前该疗法中最具潜力的药物蛋白 ,本文综合介绍了该蛋白的结构和理化特征、生物学功能、体内分布和激活以及作用机制等方面的研究进展
The anti-angiogenic therapy of tumors inhibits the growth and metastasis of tumors through the formation of neovascularization in tumors. Endostatin is the most potent drug protein in the current therapy. This paper comprehensively introduces the structure, physicochemical characteristics, biological functions, in vivo distribution and activation, and mechanism of action of the protein.