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目的观察氯吡格雷联合阿司匹林治疗短暂性脑缺血发作的临床效果。方法将河南科技大学第一附属医院93例短暂性脑缺血发作的患者随机分为观察组47例和对照组46例。对照组采用常规方法治疗,观察组联合应用氯吡格雷和阿司匹林治疗,观察比较两组患者的血流动力学情况以及临床疗效,治疗周期是6周。结果血流动力学指标变化比较:观察组同对照组相比,降低幅度大于对照组,差异有统计学意义(P<0.05)。两组疗效比较:对照组经治疗后有效率(28/4 6)66.1 2%,观察组经治疗后有效率(38/4 7)80.85%,两组差异有统计学意义(P<0.05)。结论采用氯吡格雷和阿司匹林治疗短暂性脑缺血可以有效改善患者的脑部血液供应,使脑梗死发生概率降低,提高了患者及家属的临床满意度,值得在临床中推广。
Objective To observe the clinical effect of clopidogrel combined with aspirin in the treatment of transient ischemic attack. Methods 93 cases of transient ischemic attack in the First Affiliated Hospital of Henan University of Science and Technology were randomly divided into observation group (n = 47) and control group (n = 46). The control group was treated by conventional method. The observation group was treated with clopidogrel and aspirin. The hemodynamics and clinical efficacy of the two groups were observed and compared. The treatment cycle was 6 weeks. Results The changes of hemodynamics indexes: Compared with the control group, the reduction rate of the observation group was larger than that of the control group, the difference was statistically significant (P <0.05). The curative effect of the two groups was 66.1% (66/62) in the control group and 80.85% (38/47) in the observation group after treatment, the difference between the two groups was statistically significant (P0.05) . Conclusion The treatment of transient ischemic attacks with clopidogrel and aspirin can effectively improve the brain blood supply, reduce the probability of cerebral infarction and improve the clinical satisfaction of patients and their families, which is worth to be popularized clinically.