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前列腺素(PG)和白三烯(LT)是花生四烯酸(AA)分别经环氧酶(CO)和5-脂氧酶(5-LPO)代谢途经形成的两大类具有高度生物活性的自调物质(autocoid)。它们按机体的需要,由组织迅速形成,通常就在局部发挥作用,并随即被代谢灭活。自本世纪六十年代以来,相继发现了AA代谢物对肾的生理效应。近几年随着实验手段的不段改善,对肾脏各部位AA代谢的情况及其作用了解愈加深入,对影响肾脏AA代谢的因素的研究也有
Prostaglandins (PGs) and leukotrienes (LTs) are two major classes of compounds that are highly bioactive in the metabolism of arachidonic acid (AA) by cyclooxygenase (CO) and 5-lipoxygenase (5-LPO) Of the autocoid. Depending on the needs of the body, they are rapidly formed by the tissue and usually function locally and are subsequently inactivated by metabolism. Since the sixties of this century, have been found AA metabolites of the physiological effects of the kidneys. In recent years, with the experimental means of improvement, the metabolism of the various parts of the kidney AA understanding of the situation and its role in-depth understanding of the factors that affect the metabolism of kidney AA