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目的比较硝苯地平缓释片联合卡托普利、硝苯地平缓释片、卡托普利治疗原发性高血压的临床疗效。方法选择2008年1月-2011年8月我院门诊和住院的原发性高血压患者共270例,随机分为3组,分别给予硝苯地平缓释片与卡托普利联合治疗、硝苯地平缓释片单药治疗和卡托普利单药治疗,疗程4W后对比观察降压疗效、不良反应。结果联合用药组总有效率93.33%,与各单药治疗组比较差异均有统计学意义(P<0.05),且不良反应少,耐受性好。结论硝苯地平缓释片与卡托普利联合治疗原发性高血压疗效显著,不良反应较少,在基层及社区卫生服务机构有应用前景。
Objective To compare the clinical efficacy of nifedipine sustained release tablets combined with captopril, nifedipine sustained release tablets and captopril in the treatment of essential hypertension. Methods A total of 270 essential hypertension patients were selected from January 2008 to August 2011 in our hospital and were randomly divided into 3 groups and were given nifedipine combined with captopril, Benidipine sustained-release tablets monotherapy and captopril monotherapy, after 4W contrast treatment of antihypertensive efficacy, adverse reactions. Results The total effective rate was 93.33% in the combination group, with statistical significance (P <0.05) compared with the single drug treatment group, with less adverse reactions and good tolerability. Conclusion The combination of nifedipine sustained-release tablets and captopril has a significant effect in treating essential hypertension with fewer adverse reactions, and has potential applications in grassroots and community health service agencies.