Indirubin-3′-monoxime suppresses amyloid-beta-induced apoptosis by inhibiting tau hyperphosphorylati

• 作 者: Shu-gang Zhang Xiao-shan Wang Ying-dong Zhang Qing Di Jing-ping Shi Min Qian Li-gang Xu Xing-jian Lin Jie Lu
• 机 构: Department of Neurology, Affiliated Nanjing Brain Hospital, Nanjing Medical University,Department of
• 出 处: Neural Regeneration Research
• 发表日期: 2016年06期
• 关键词: amyloid Indirubin-3 inhibiting neuronal suppressed glycogen inhibited suppressin

Indirubin-3′-monoxime is an effective inhibitor of cyclin-dependent protein kinases, and may play an obligate role in neuronal apoptosis in Alzheimer’s disease. Here, we found that indirubin-3′-monoxime improved the morphology and increased the survival rate of SHSY5 Y cells exposed to amyloid-beta 25–35(Aβ25–35), and also suppressed apoptosis by reducing tau phosphorylation at Ser199 and Thr205. Furthermore, indirubin-3′-monoxime inhibited phosphorylation of glycogen synthase kinase-3β(GSK-3β). Our results suggest that indirubin-3′-monoxime reduced Aβ25–35-induced apoptosis by suppressing tau hyperphosphorylation via a GSK-3β-mediated mechanism. Indirubin-3′-monoxime is a promising drug candidate for Alzheimer’s disease.

Indirubin-3’-monoxime is an effective inhibitor of cyclin-dependent protein kinases, and may play an obligate role in neuronal apoptosis in Alzheimer’s disease. Here, we found that indirubin-3’-monoxime improved the morphology and increased the survival rate of SHSY5 Y cells exposed to amyloid-beta 25-35 (Aβ25-35), and also suppressed apoptosis by reducing tau phosphorylation at Ser199 and Thr205.Moreover, indirubin-3’-monoxime inhibited phosphorylation of glycogen synthase kinase-3β (GSK-3β ) Our results suggest that indirubin-3’-monoxime reduced Aβ25-35-induced apoptosis by suppressing tau hyperphosphorylation via a GSK-3β-mediated mechanism. Indirubin-3’-monoxime is a promising drug candidate for Alzheimer’s disease.