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目的探讨细胞周期蛋白依赖性激酶2(CDK2)在鼻咽癌和慢性鼻咽炎黏膜组织中的表达水平,及其与鼻咽癌的临床病理关系。方法免疫组化SP法检测CDK2蛋白在鼻咽癌和慢性鼻咽炎黏膜组织中的表达情况。结果 CDK2蛋白阳性表达主要定位于细胞核,少数有胞浆着色,呈棕黄色或棕褐色不同强度的染色。62例鼻咽癌组织中阳性表达率为69.4%(43/62),慢性鼻咽炎黏膜组织中阳性率为32.0%(9/28),两组间差异有统计学意义(P<0.05)。CDK2蛋白表达与鼻咽癌分化程度,淋巴结转移范围,TNM分期有关(P<0.05)。结论 CDK2在鼻咽癌组织中的表达明显高于慢性鼻咽炎黏膜组织中的表达,提示CDK2与鼻咽癌的发生、发展有关。CDK2与鼻咽癌分化程度,淋巴结转移范围,TNM分期有关。
Objective To investigate the expression of cyclin dependent kinase 2 (CDK2) in nasopharyngeal carcinoma and chronic nasopharyngitis mucosa and its clinicopathological relationship with nasopharyngeal carcinoma. Methods Immunohistochemical SP method was used to detect the expression of CDK2 protein in nasopharyngeal carcinoma and chronic nasopharyngitis mucosa. Results The positive expression of CDK2 protein mainly located in the nucleus, with a few cytoplasm coloration, brown or tan different intensity staining. The positive rate of 62 nasopharyngeal carcinoma tissues was 69.4% (43/62), and the positive rate of chronic nasopharyngitis mucosal tissues was 32.0% (9/28). The difference between the two groups was statistically significant (P <0.05). CDK2 protein expression and nasopharyngeal carcinoma differentiation, lymph node metastasis, TNM stage (P <0.05). Conclusion CDK2 expression in nasopharyngeal carcinoma was significantly higher than that in chronic nasopharyngitis mucosa, indicating that CDK2 is associated with the occurrence and development of nasopharyngeal carcinoma. CDK2 and nasopharyngeal carcinoma differentiation, lymph node metastasis, TNM staging.