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目的:评价应用大剂量甲钴胺对糖尿病患者心率变异性的影响。方法:收集糖尿病患者64例,分为治疗组和对照组,治疗组患者静脉注射甲钴胺1mg,每天2次,连用2周后改为口服0.5mg,每天3次。总疗程为4周。运用24h动态心电图检测所有患者在治疗前后心率变异性指标的变化,明确甲钴胺治疗糖尿病心脏自主神经病变的疗效。结果:治疗组心率变异性各项指标治疗4周后较治疗前有显著提高,自主神经症状明显好转,与对照组比有显著统计学意义(P<0.01)。结论:甲钴胺治疗糖尿病心脏自主神经病变的疗效显著,可以改善患者的心率变异性。
Objective: To evaluate the effect of high-dose mecobalamin on heart rate variability in patients with diabetes mellitus. Methods: Sixty-four patients with diabetes mellitus were divided into treatment group and control group. The patients in the treatment group received intravenous methylcobalamin 1 mg twice daily for 2 weeks and then orally taken 0.5 mg three times a day. The total course of treatment is 4 weeks. 24h Holter monitoring of all patients before and after treatment of heart rate variability index changes, a clear mecobalamin treatment of diabetic cardiac autonomic neuropathy effect. Results: After treatment for 4 weeks, the indexes of heart rate variability in treatment group were significantly improved compared with that before treatment, and the symptoms of autonomic nerve improved obviously, which was significantly higher than that of control group (P <0.01). Conclusion: Mecobalamin treatment of diabetic autonomic neuropathy significant effect, can improve the patient’s heart rate variability.