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目的探讨p73基因甲基化在急性淋巴细胞白血病(ALL)发病机制中的作用。方法对吉林大学第二医院2001~2004年42例ALL患者采用限制性内切酶结合多聚酶链反应方法(REP)检测p73基因第一外显子甲基化情况。结果42例ALL患者甲基化检测结果28.6%(12/42),存在p73甲基化患者化疗前周围血白细胞数及骨髓原始细胞数均高于无p73甲基化患者,而且首次化疗即获完全缓解及平均缓解时间较无甲基化者差异有显著性。结论p73基因甲基化在ALL发病机制中有一定的作用。其检测对估计预后具有临床意义。
Objective To investigate the role of p73 gene methylation in the pathogenesis of acute lymphoblastic leukemia (ALL). Methods 42 patients with ALL from 2001 to 2004 in the Second Hospital of Jilin University were enrolled in this study. The first exon methylation of p73 gene was detected by restriction endonuclease-linked polymerase chain reaction (REP). Results The methylation detection results of 42 patients with ALL were 28.6% (12/42). There was a significant increase in peripheral blood leukocytes and myeloid blasts in patients with p73 methylation before chemotherapy and in the first chemotherapy The complete remission and the average remission time were significantly different from those without methylation. Conclusion The p73 gene methylation has a certain role in the pathogenesis of ALL. The detection of the prognosis of clinical significance.