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目的探讨大剂量丙种球蛋白联合干扰素治疗重症小儿手足口病并病毒性脑炎对患儿脑脊液和血清S100B、神经特异性烯醇化酶(NSE)水平的影响。方法将重症小儿手足口病并病毒性脑炎患儿184例随机分为研究组和对照组各92例,对照组采取常规治疗和干扰素治疗,研究组在对照组的治疗基础上联合大剂量丙种球蛋白治疗,比较2组患者治疗前后血清脑脊液和血清S100B、NSE水平。结果治疗后2组脑脊液和血清S100B、NSE水平较治疗前均明显下降(P<0.05);研究组脑脊液和血清S100B、NSE水平显著低于对照组(P<0.05)。结论大剂量丙种球蛋白联合干扰素治疗重症小儿手足口病并病毒性脑炎能有效地降低患儿脑脊液和血清S100B、NSE水平。
Objective To investigate the effects of high-dose gamma globulin combined with interferon on cerebrospinal fluid (CSF), serum S100B and neuron-specific enolase (NSE) levels in children with HFMD and viral encephalitis. Methods A total of 184 children with HFMD and viral encephalitis were randomly divided into study group (92 cases) and control group (n = 92). The control group received routine treatment and interferon treatment. The study group was treated with high dose Gamma globulin treatment, serum and cerebrospinal fluid and serum S100B, NSE levels were compared between two groups before and after treatment. Results The levels of S100B and NSE in CSF and serum of two groups were significantly decreased after treatment (P <0.05). The levels of S100B and NSE in CSF and serum in the study group were significantly lower than those in the control group (P <0.05). Conclusion High-dose gamma-globulin combined with interferon in the treatment of HFMD and viral encephalitis in children can effectively reduce the levels of S100B and NSE in cerebrospinal fluid and serum.