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目的：揭示抑制素α亚基（ＩＮＨα）在卵巢恶性肿瘤和正常卵巢中的分泌来源。方法：用自制的ＩＮＨα单克隆抗体（ＭｃＡｂ）．建立ＬＳＡＢ免疫组化染色法，对１８例卵巢恶性肿瘤扣７例正常卵巢进行ＩＮＨα免疫定位。结果：光镜下见正常卵巢粒层细胞和黄体细胞内存在强阳性免疫染色反应。绝经后的卵巢内仅呈很弱的阳性；卵巢恶性肿瘤细胞中则呈明显的强阳性染色。阳性着色主要分布在胞浆，胞膜和胞核也有着色，其中恶性细胞胞核着色最为明显。结论：卵巢恶性肿瘤细胞产生ＩＮＨα样物质，ＩＮＨα具有旁分泌和自分泌生长因予作用。
Objective: To reveal the source of inhibin α subunit (INHα) in ovarian cancer and normal ovary. Methods: Using homemade INHα monoclonal antibody (McAb). Establish LSAB immunohistochemical staining, 18 cases of ovarian cancer buckle normal ovarian INHα immune localization. Results: There was a strong positive immunostaining reaction in normal ovarian granulosa cells and luteal cells under light microscope. Postmenopausal ovarian only showed a weak positive; ovarian cancer cells showed a strong positive staining. Positive staining mainly in the cytoplasm, membrane and nucleus also have coloring, the most obvious staining of malignant cells in the nucleus. CONCLUSION: INHα-like substances are produced in ovarian cancer cells. INHα has paracrine and autocrine growth factors.