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目的探讨大肠癌术前化疗的方法及疗效．方法本院同期手术治疗的１１４例大肠癌病例，根据术前化疗方法分为：Ａ动脉灌注化疗组６２例；Ｂ静脉化疗组１９例；Ｃ５氟脲嘧啶（５ＦＵ）保留灌肠组１２例；Ｄ对照组２１例．化疗后２ｗｋ～４ｗｋ行肿瘤切除术，肿瘤标本做病理切片组织学疗效观察．结果Ａ，Ｂ，Ｃ组化疗后切除的肿瘤其细胞变性、坏死数量及程度均明显高于对照组（Ｐ＜００１），其中动脉灌注化疗组高于静脉化疗组和５ＦＵ保留灌肠组（Ｐ＜００５）．４０例使用５ＦＵ的动脉灌注化疗组中８例出现化学性肠炎，其中２例出现肠缺血坏死．结论大肠癌术前化疗以动脉灌注化疗疗效最好，应作为首选；５ＦＵ作为大肠癌术前动脉灌注化疗用药疗效不显著而副作用明显，应避免使用．
Objective To explore the method and effect of preoperative chemotherapy for colorectal cancer. Methods 114 patients with colorectal cancer who underwent surgery in this hospital were divided into two groups according to preoperative chemotherapy: 62 in the A arterial infusion chemotherapy group, 19 in the B intravenous chemotherapy group, and 5 in the C5fluorouracil retention enema group. Cases; D control group of 21 cases. Tumor resection was performed after chemotherapy for 2 weeks to 4 weeks. Tumor specimens were observed for pathological histological observation. Results The number and degree of cell degeneration and necrosis in tumors resected after chemotherapy in group A, B, and C were significantly higher than those in the control group (P<0.01). Arterial infusion chemotherapy group was superior to intravenous chemotherapy group and 5-FU retention enema. Group (P<005). Forty patients with 5FU arterial infusion chemotherapy received chemical enteritis in 8 cases, of which 2 cases developed intestinal ischemia necrosis. Conclusions Preoperative chemotherapy for arterial colorectal cancer is the best for arterial infusion chemotherapy and should be the first choice; 5 FU has no obvious curative effect on preoperative arterial infusion chemotherapy for colorectal cancer, but has obvious side effects and should be avoided.