酚妥拉明治疗肝硬化食道胃底静脉曲张出血的研究

• 出 处: 同济医科大学学报
• 发表日期: 1990年02期
• 关键词: 妥拉 门脉血管阻力 肝硬化门脉高压 垂体后叶素 大出血患者 肾上腺素能受体 血浆儿茶酚胺 去甲 受体拮抗剂 中亦

作者在建立狗肝硬化门脉高压模型、观察实验前后血浆儿茶酚胺(CA)、去甲肾上腺索(NE)及肾上腺素(E)的动态变化及其对门脉血管阻力所起作用的基础上,用相应的α肾上腺素能受体持抗剂酚妥拉明治疗人肝硬化食道静脉曲张破裂大出血患者14例,结果12例未再出现呕血,从胃管中亦未再抽出血性胃液,大便一般于用药2～3日后由黑转黄。其降低门脉压及近期止血效果不亚于垂体后叶素,且无后者的严重

On the basis of establishing a model of portal hypertension in dogs with cirrhosis and observing the dynamic changes of plasma catecholamine (CA), norepinephrine (NE) and epinephrine (E) and their effects on portal resistance before and after the experiment, With the corresponding α-adrenergic receptor antagonist phentolamine treatment of cirrhosis in patients with cirrhosis esophageal variceal bleeding in 14 patients, the results of 12 patients no recurrence of hematemesis, gastric tube also did not extract bloody gastric fluid, the general stool After the medication 2 to 3 days from black to yellow. Its lower portal pressure and the recent hemostatic effect as much as pituitrin, and the latter is not serious