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目的探讨基质金属蛋白酶-9(MMP-9)与急性冠状动脉综合征(ACS)的关系。方法分别利用酶联免疫吸附法对32例急性冠状动脉综合征(ACS)组,30例稳定型心绞痛(SAP)组,22例非冠心病者(正常对照组)外周血清MMP-9水平进行测定。结果ACS组的血清MMP-9水平明显高于SAP组和正常对照组,差异具有统计学意义。结论血清MMP-9水平可反映斑块稳定性,可作为检测ACS的血清学指标。
Objective To investigate the relationship between MMP-9 and acute coronary syndrome (ACS). Methods Peripheral serum MMP-9 levels were measured by enzyme-linked immunosorbent assay in 32 patients with acute coronary syndrome (ACS), 30 patients with stable angina (SAP) and 22 patients with non-coronary heart disease (normal control group) . Results The serum level of MMP-9 in ACS group was significantly higher than that in SAP group and normal control group, the difference was statistically significant. Conclusion Serum MMP-9 level can reflect the stability of plaque, which can be used as a serological index for detecting ACS.