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目的:选择临床报告过敏性休克排名较前的7种中药注射剂进行Beagle犬类过敏反应试验(anaphylactoid reaction),并探讨聚山梨酯80(Tween 80)对中药注射剂致敏性的影响。方法:通过一次静脉恒速注射各种中药注射剂,观察Beagle犬的反应症状,检测血浆中组胺、免疫球蛋白E(immunoglobulin E,IgE)、免疫球蛋白G(immunoglobulin,IgG)和免疫球蛋白M(immunoglobulin M,IgM)含量。结果:根据行为症状和组胺含量升高综合判断为类过敏反应强阳性者有含Tween 80的鱼腥草、脉络宁和复方丹参注射剂,其他为阳性。结论:7种中药注射剂均出现类过敏反应,吐温80是导致含Tween 80的中药注射剂类过敏反应的主要诱因之一,但非惟一原因,尚存在一些其他诱发物质,需进一步研究。
OBJECTIVE: To select the anaphylactoid reaction of seven kinds of traditional Chinese medicine injections which were clinically reported to have anaphylactic shock, and investigate the effect of Tween 80 on the sensitization of traditional Chinese medicine injections. Methods: The symptoms of Beagle dogs were observed by a single intravenous injection of various traditional Chinese medicine injections. Histamine, immunoglobulin E (IgE), immunoglobulin (IgG) and immunoglobulin M (immunoglobulin M, IgM) content. Results: Houttuynia, Mailuoning and Fufang Danshen injection containing Tween 80 were all judged to be positive according to the behavioral symptoms and histamine increase. CONCLUSIONS: Allergic reactions occur in all 7 Chinese traditional medicine injection. Tween 80 is one of the main causes of allergic reaction of traditional Chinese medicine injection containing Tween 80. However, there are still some other inducing agents that need to be further studied.