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Cunninghamella elegans has been employed for the biotransformation of cinobufagin (1) to afford one metabolites.The structure of the transformation product has been characterized as 7β,12β-dihydroxylcinobufagin (2).Product 2 is a new compound. In vitro cytotoxic activities of the biotransformation product and the substrate-cinobufagin have been assayed against HeLa;they all showed cytotoxic activities.
Cunninghamella elegans has been employed for the biotransformation of cinobufagin (1) to afford one metabolites. The structure of the transformation product has been characterized as 7β, 12β-dihydroxylcinobufagin (2). Product 2 is a new compound. In vitro cytotoxic activities of the biotransformation product and the substrate-cinobufagin have been assayed against HeLa; they all showed cytotoxic activities.