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目的探讨解脲脲原体感染(UU)在早产儿支气管肺发育不良发生的相关性及其预后。方法选取2013年6月-2014年6月间该院收治的早产儿585例,根据两组早产儿UU感染情况分为UU感染组180例、UU非感染组405例。比较两组患儿UU感染相关的临床特点,分析UU感染与支气管肺发育不良(BPD)发生之间的相关性,对中度、重度BPD患儿随访至出生后1年,观察其预后情况。结果 UU感染组中孕妇自然分娩率、胎膜早破率明显高于非UU感染组,新生儿呼吸窘迫综合征(NRDS)发生率、使用肺表面活性物质率明显低于非UU感染组,差异均有统计学意义(P<0.01)。UU感染者BPD的发生率明显高于非UU感染者,差异有统计学意义(P<0.01)。UU感染组BPD患儿中度和重度比例均明显高于非UU感染组,差异有统计学意义(P<0.05)。重度BPD患儿出生1年内随访显示,两组喘息发作率、肺部感染率、再次入院情况、死亡率之间差异均无统计学意义(P>0.05)。结论 UU感染者BPD的发生率及严重程度明显高于无UU感染者;但UU感染的BPD与非UU感染的BPD预后情况基本一致。
Objective To investigate the correlation and prognosis of UU in premature infants with bronchopulmonary dysplasia. Methods 585 premature infants admitted to our hospital from June 2013 to June 2014 were divided into UU infection group (180 cases) and UU non-infection group (405 cases) according to the UU infection status of the two groups. The clinical features of UU infection were compared between the two groups. The correlation between UU infection and the occurrence of bronchopulmonary dysplasia (BPD) was analyzed. The children with moderate and severe BPD were followed up to 1 year after birth and the prognosis was observed. Results The rate of spontaneous delivery and the rate of premature rupture of membranes in UU infection group were significantly higher than those in non-UU infection group and neonatal respiratory distress syndrome (NRDS). The rate of pulmonary surfactant utilization was significantly lower than that of non-UU infection group All were statistically significant (P <0.01). The incidence of BPD in UU infected patients was significantly higher than that in non-UU infected patients, the difference was statistically significant (P <0.01). The moderate and severe rates of BPD in UU infection group were significantly higher than those in non-UU infection group, the difference was statistically significant (P <0.05). One year follow-up of children with severe BPD showed that there was no significant difference between the two groups in the rates of wheezing, lung infection, re-admission, and mortality (P> 0.05). Conclusions The incidence and severity of BPD in patients with UU infection are significantly higher than those without UU infection; however, the prognosis of BPD patients with UU infection is basically the same as that of non-UU patients.