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目的探讨多潘立酮(Dom)对正常人胆囊(GB)排空功能的影响。方法采用随机、双盲及自身对照的方法,应用超声检查研究了 Dom 对正常人 GB 排空功能的作用。结果口服 Dom 后 GB 排空减慢,餐后30min 20mg Dom(Dom_2)使 GB排出量(GBEF)明显减少(P<0.05),餐后60min 减少更著(P<0.01)。10mg Dom(Dom_1)虽使 GBEF 减少,但不显著(P>0.05)。GBEF 减少Dom_2明显较 Dom_1为著(P<0.05-0.01)。餐后60min Dom_2使 GB 排空速度明显较未服 Dom 及 Dom_1为慢(P<0.05)。最大 GBEF Dom_2显著少于未服 Dom 及 Dom_1(P<0.01)。结论口服 Dom_2具有显著地减少GB 排空的作用。本研究为 Dom 的合理应用提供理论根据。
Objective To investigate the effect of domperidone on the emptying function of gallbladder (GB) in normal people. Methods A randomized, double-blind and self-control method was used to study the effects of Dom on GB emptying function in normal subjects. Results After oral administration of Dom, the emptying of GB slowed down. After 20 mg of Dom (Dom 2) for 30 min, the GBEF significantly decreased (P <0.05) and decreased more significantly after 60 min (P <0.01). Although 10 mg Dom (Dom_1) reduced GBEF, it was not significant (P> 0.05). Dom-2 was significantly reduced by Dom-2 compared with Dom-1 (P <0.05-0.01). At 60 min after meal, Dom 2 evacuated GB significantly faster than Dom and Dom 1 (P <0.05). The maximal GBEF Dom_2 was significantly less than Dom and Dom_1 (P <0.01). Conclusion Oral administration of Dom 2 significantly reduced GB emptying. This study provides a theoretical basis for the reasonable application of Dom.