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目的 :探讨非甲 -戊型、非庚型肝炎病原诊断 ,了解慢性乙肝、献血员和体检者TTV现症感染状况 ,分析 TTV感染表现形式。方法 :对比调查非甲 -戊型、非庚型肝炎患者2 5例、慢性乙肝 63例、献血员 3 0例及体检者 3 2例 TTV感染情况。结果 :4组中 TTV DNA检出率各为 5 2 .0 0 % (1 3 / 2 5 )、1 5 .87% (1 0 / 63 )、1 0 .0 0 % (3 / 3 0 )和 3 .1 3 % (1 / 3 2 ) ,非甲 -戊型、非庚型肝炎组与其它 3组比较 P均 <0 .0 1。结论 :TTV系非甲 -戊型 ,非庚型肝炎病因之一 ,其致病力较弱。单纯 TTV感染引起慢性肝炎 47.0 6% (8/ 1 7) ,急性肝炎 2 3 .5 3 % (4 /1 7)、病原携带状态或隐性感染 2 3 .5 3 % (4 / 1 7) ,重型肝炎最少 5 .88% (1 / 1 7)明显少于慢性肝炎 (P<0 .0 1 )。
Objective: To investigate the pathogen diagnosis of non-A-type and non-G-type hepatitis and to find out the prevalence of TTV infection in chronic hepatitis B, blood donors and physical examinations, and to analyze the manifestations of TTV infection. Methods: Twenty-five non-A-type hepatitis patients, 63 non-hepatitis B patients, 63 chronic hepatitis B patients, 30 blood donors and 32 TTV infection cases were examined. Results: The detection rates of TTV DNA in four groups were 52.0% (1 3/2 5), 15.87% (1 0/63), 100.0% (3/30) And 3 .1 3% (1/3 2), P <0. 01 in non-A-type and non-G-type hepatitis group compared with the other 3 groups. Conclusion: TTV is one of the causes of non-A-E and non-G hepatitis, its pathogenicity is weak. Pure TTV infection caused chronic hepatitis 47.0 6% (8/17), acute hepatitis 23.53% (4/17), pathogen infection or recessive infection 23.5% (4/1 7) , At least 5.88% (1/7) of severe hepatitis were significantly less than those of chronic hepatitis (P <0.01).