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近年来随着氧自由基(OFR)对细胞损害及导致疾病等方面认识的逐步加深,其在哮喘发病中所起的作用也愈来愈受到重视。大量研究表明,气道炎症和气道高反应是发生支气管哮喘的重要因素,OFR则作为一种主要炎性介质在哮喘发病中起着重要作用。正常机体在生理情况下,有部分氧分子在代谢过程中因仅接受单电子而生成活性氧代谢物,即OFR,包括超氧阴离子(O_2),过氧化氢(H_2O_2),羟自由基(HO·)与单线态氧(~1O_2)。由于机体同时存在着自由基清除系统,故始终保持着动态平衡。若一旦发生病理情况,例如接触过敏原、感染等,即可诱使OFR 产生量增加和/或机体抗氧化能力下降,导致细胞与组织器官损害,引起一系列症状。
In recent years, as oxygen free radicals (OFR) on cell damage and lead to progressive understanding of disease and other aspects, its role in the pathogenesis of asthma are also more and more attention. A large number of studies have shown that airway inflammation and airway hyperresponsiveness are important factors in the development of bronchial asthma. OFR plays an important role as a major inflammatory mediator in the pathogenesis of asthma. In the physiological condition, some oxygen molecules generate reactive oxygen species (OFRs), including superoxide anion (O_2), hydrogen peroxide (H_2O_2), hydroxyl radical ·) And singlet oxygen (~ 1O_2). Because the body also exists free radical scavenging system, it has always maintained a dynamic balance. Once the pathological conditions, such as exposure to allergens, infections, etc., can induce increased OFR production and / or body antioxidant capacity, resulting in damage to cells and tissues and organs, causing a range of symptoms.