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以研究汉方方剂及生药制剂的抗促癌活性为目的,对用于呼吸系统或上呼吸道粘膜疾患的数种汉方方剂进行了筛选。结果发现,经口给予小青龙汤后,能明显抑制小鼠皮肤及肺二阶段致癌。进一步用从小青龙汤组成生药细辛中分离的(-)-细辛素、(-)-花椒酚(xanthoxylol),对小鼠皮肤二阶段致癌有明显的抑制作用。从细辛的脂溶性组分中分离的这2种化合物,在小青龙汤煎液中的浓度
In order to study the anti-cancer activity of Kampo prescription and crude drug preparations, several Kampo prescriptions for respiratory system or upper respiratory mucosal diseases were screened. As a result, it was found that oral administration of Xiaoqinglong Decoction significantly inhibited the carcinogenicity of mouse skin and lung. Furthermore, (-)-Ascotne, (-)-Zanthoxylol (Xanthoxylol) isolated from Xiaoqinglong Decoction Herbal Asarum was used to significantly inhibit the carcinogenesis of mice. The concentration of the two compounds isolated from the fat-soluble components of Asarum in the decoction of Xiaoqinglong Decoction