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目的:探讨VCP蛋白表达与胃癌预后的关系,确立VCP作为判断胃癌预后的独立因子作用。方法:在187例胃癌组织手术标本中进行VCP的免疫组织化学染色,比较肿瘤细胞和正常血管内皮细胞VCP的表达,并结合肿瘤浸润、转移、预后等临床因素进行分析比较。结果:VCP的表达与胃癌的浸润、淋巴结转移相关,单变量分析中年龄、胃癌的浸润深度、脉管浸润、淋巴结转移及远处转移等因素显示与胃癌的预后相关(P<0．05),多变量分析显示了VCP表达水平较肿瘤的分化、淋巴结浸润、转移与胃癌预后相关的危险系数高,故VCP的表达更能反映胃癌的预后。结论:VCP的表达是胃癌重要、独立的预后因子。
Objective: To investigate the relationship between the expression of VCP and the prognosis of gastric cancer and to establish VCP as an independent factor to evaluate the prognosis of gastric cancer. Methods: Immunohistochemical staining of VCP was performed in 187 specimens of gastric cancer. The expression of VCP in tumor cells and normal vascular endothelial cells was compared with clinical parameters of tumor invasion, metastasis and prognosis. Results: The expression of VCP was correlated with the infiltration of gastric cancer and lymph node metastasis. The age, the depth of gastric cancer invasion, vascular invasion, lymph node metastasis and distant metastasis in univariate analysis were correlated with the prognosis of gastric cancer (P <0.05) Multivariate analysis showed that the expression level of VCP was higher than that of tumor differentiation, lymph node invasion and metastasis and the prognosis of gastric cancer. Therefore, the expression of VCP could better reflect the prognosis of gastric cancer. Conclusion: VCP expression is an important and independent prognostic factor for gastric cancer.