S4B-4 A Novel Allosteric Phosphodiesterase 4D Inhibitor BPN14770 Reverses Cognitive Impairment in Hu

• 作 者: XU Ying ZHANG Chong YANG Ming-
• 机 构: DepartmentofPharmaceuticalSciences,DepartmentsofBehavioralMedicine&,PsychiatryandPhysiology,Tetra
• 出 处: 神经药理学报
• 发表日期: 2018年4期
• 关键词: HUMANIZED PDE4D(hPDE4D)mice byβ-amyloid PEPTIDE 1-42

Classical inhibitors of PDE4 lack subtype selectivity due to exact amino acid sequence conservation of the catalytic site,and consequently,development of these drugs has stalled due to dose-limiting side effects of nausea and emesis.While use of subtype-s