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目的检测Survivin在子宫腺肌病组织中的表达情况,探讨Survivin与子宫腺肌病发病的关系。方法选择2009年2月—2013年1月收治的子宫腺肌病病灶标本50例作为研究对象(观察组),同期选择正常子宫内膜标本50例作为正常对照(对照组),2组都进行Survivin表达检测,然后进行表达得分与阳性率对比。结果 Survivin在观察组及对照组中均有表达,主要表达在内膜腺上皮细胞的胞质中,其得分分别为(1.52±0.23)vs(0.45±0.22)。经过对比,观察组的survivin表达得分显著高于对照组(t=23.772,P<0.01);观察组的Survivin表达阳性率(60.0%)明显高于对照组(14.0%),2组的差异均有统计学意义(χ2=22.694,P<0.01)。随访6个月,观察组患者的复发率(20.0%)明显高于对照组患者,2组的差异有统计学意义(χ2=19.852,P<0.05)。结论 Survivin在子宫腺肌病组织中异常表达对子宫腺肌病的发生起重要作用,其过度表达可能是导致子宫腺肌病的原因之一。
Objective To detect the expression of Survivin in adenomyosis and investigate the relationship between Survivin and adenomyosis. Methods Fifty cases of adenomyosis from February 2009 to January 2013 were selected as observation group (observation group), and 50 cases of normal endometrium were selected as normal control group (control group) in the same period, and both groups were performed Survivin expression was detected, and then compared with the positive expression rate score. Results Survivin was expressed in both the observation group and the control group, and was mainly expressed in the cytoplasm of endometrial glandular epithelial cells with a score of (1.52 ± 0.23) vs (0.45 ± 0.22), respectively. In contrast, the expression of survivin in the observation group was significantly higher than that in the control group (t = 23.772, P <0.01); the positive rate of Survivin expression in the observation group was significantly higher than that in the control group (60.0%, 14.0% There was statistical significance (χ2 = 22.694, P <0.01). The follow-up of 6 months showed that the recurrence rate (20.0%) in the observation group was significantly higher than that in the control group. There was significant difference between the two groups (χ2 = 19.852, P <0.05). Conclusions Abnormal expression of Survivin in adenomyosis plays an important role in the development of adenomyosis. Overexpression of Survivin may be one of the causes of adenomyosis.