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本研究用内皮素-1（ET－1）引起动物的急性死亡、升压及编血管作用为模型，以评价中草药桔抗ET生物效能，并用红背丝绸醇提物在该模型上进行了验证。结果表明，红背丝绸醇提物能减少ET－1引起的小鼠死亡数并延长死亡时间、降低ET－1的升压效应，并在体外有桔抗ET－1的缩血管作用。提示中草药具有桔抗内皮素-1的效能。
In this study, acute death, ascending blood pressure and angiogenesis induced by endothelin-1 (ET-1) were used as models to evaluate the bio-efficacy of Chinese herbal medicine anti-ET and validated on this model with red-backed silk alcohol extract . The results showed that the alcohol extract of red silk could reduce the number of mice killed by ET-1 and prolong the death time, reduce the vasopressor effect of ET-1 and inhibit the vasoconstriction of ET-1 in vitro. Tip Chinese herbal medicine with anti-endothelin-1 efficacy.