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家兔、大鼠和金色田鼠在受孕后第7或5天,各注射长效15-甲基前列腺素F_(2α)(简称15-甲PGF_(2α))1mg/kg,2mg/kg,2mg/kg,并分别在第17、16和12天剖检黄体和胚胎发育情况。胚胎数对照组分别为12.3±0.4,13.1±0.8和14.7±0.7,给药组分剐为0,0和0.7±0.7,死胎数对照组分别为0,给药组分别为8.4±2.2,8.0±0.6和0.5±0.5,生育率对照组分别为7/7,9/10和10/10,给药组分别为0/7,0/10和1/10。受孕兔、假孕兔和受孕鼠均在第7天肌肉注射15-甲PGF_(2α)(1mg/kg)后,血浆孕酮水平均明显下降,黄体均成为白体,说明长效15-甲PGF_(2α)有明显的溶黄体作用。
Rabbits, rats and golden voles were injected with either 1 mg / kg of long-acting 15-methyl prostaglandin F 2α (abbreviated 15-A PGF 2α) 2mg / kg, 2mg / kg on day 7 or 5 after conception / kg, respectively, and on the 17th, 16th and 12th days respectively, the corpus luteum and embryo development were examined. The number of embryos was 12.3 ± 0.4, 13.1 ± 0.8 and 14.7 ± 0.7, respectively, and the control group was 0,0 and 0.7 ± 0.7 respectively. The number of stillbirths was 0 in control group and 8.4 ± 2.2 and 8.0 in control group ± 0.6 and 0.5 ± 0.5, respectively. The fertility control groups were 7/7, 9/10, and 10/10, respectively, and the administration groups were 0/7, 0/10 and 1/10, respectively. After injection of 15-A PGF 2α (1 mg / kg) intramuscularly on the 7th day, the levels of progesterone in the pregnant rabbits, the pseudobiotics pregnant rabbits and the conception pregnant rats all decreased obviously and the corpus luteum became white body, indicating that the long-acting 15- PGF_ (2α) has obvious role in the corpus luteum.