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进行四项试验观察Baycox对柔嫩艾美尔球虫的作用及其对球虫免疫力影响。Baycox均以推荐浓度(25ppmToltrazuril)混入水中任鸡自由饮用。以2000卵囊剂量感染并立即给药的鸡,在感染后6-20d粪便中始终没有发现卵囊,表明Bayoox具有杀虫作用而不是抑虫作用。以8×10 ̄4卵囊剂量感染鸡,在感染前1d和感染后0、1、2、3、4、5d分别开始给药,根据血便数量和盲肠病变判断,Baycox的作用峰期是在感染后0-2d之间。感染后第4d再给药已无治疗作用。停药1d后,药物残效对感染仍显出一定的抗球虫作用,但是停药2d后,这种作用即基本消失。采用攻毒的方法表明Baycox不影响抗球虫免疫力的形成。
Four experiments were conducted to investigate the effects of Baycox on Ctenopharyngodon idellus and its effect on coccidiosis immunity. Baycox are recommended concentrations (25ppmToltrazuril) into the water free to drink chicken. Chickens infected at 2000 oocysts with immediate administration had no oocysts found in the feces of 6-20 days after infection, indicating that Bayoox has insecticidal rather than pest-repelling effects. The chickens were inoculated with 8 × 10 ~ 4 oocysts, and were administered 1 day before infection and 0, 1, 2, 3, 4 and 5 days after infection. According to the number of bloody stools and the caecum lesions, the peak period of Baycox was 0-2d after infection. Infected 4d after treatment has no therapeutic effect. Drug withdrawal 1d, the drug residue still shows some anti-coccidial effect on infection, but after stopping 2d, this effect is basically disappeared. The method of challenge shows that Baycox does not affect the formation of anti-coccidiosis immunity.