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甲味硫脲(Metiamide)是一种组织胺H_2受体拮抗剂,已证明对十二指肠溃疡在消除症状和溃疡愈合方面效果较好。但H_2-受体拮抗剂对胃溃疡的愈合尚未有报告。Cimetidine是一种非硫脲类的H_2-受体拮抗剂,能使人体胃酸分泌减少。作者对10例良性胃溃疡患者使用口服Cimetidine治疗,每次0.2～0.4克,每日4次,共治疗6周。除给予抗酸药片外,停用其它一切药物。治疗前后均进行内窥镜检查。对其中5例急性萎缩性胃炎者尚进行了胃酸分泌量(以五肽胃泌素作刺激剂)及胃粘膜电位差测定。
Metiamide, a histamine H 2 receptor antagonist, has been shown to work well for the resolution of symptoms and ulceration of duodenal ulcers. However, the healing of gastric ulcer by H2-receptor antagonists has not been reported yet. Cimetidine is a non-thiourea H 2 -receptor antagonist that reduces gastric acid secretion in the body. The authors treated 10 patients with benign gastric ulcer by oral Cimetidine treatment, each 0.2 to 0.4 grams, 4 times a day for a total of 6 weeks. In addition to given antacid tablets, disable all other drugs. Before and after treatment were carried out endoscopy. In 5 cases of acute atrophic gastritis were still gastric acid secretion (pentagastrin as stimulant) and gastric mucosal potential difference measured.