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目的探讨血浆Klotho(KL)水平与IR的相关性。方法将研究对象分为T2DM组220例,对照(NC)组76名,采用双抗体夹心ELISA检测血浆KL水平,并测定血压、血脂及肾功能等,比较两组间的差异。多元逐步回归分析KL水平的影响因素。结果 T2DM组KL水平低于NC组[(4.9±0.5)vs(5.4±0.6)ng/ml,P<0.01],协方差分析后KL水平仍存在组间差异(P<0.01)。ISI和血肌酐(Scr)是KL水平的独立相关因素。结论 T2DM患者血浆KL水平降低,其水平与ISI独立相关,KL可能是一个反映患者IR及T2DM发生的监测指标。
Objective To investigate the correlation between plasma Klotho (KL) level and IR. Methods The subjects were divided into T2DM group (220 cases) and control group (NC group). The plasma KL levels were measured by double antibody sandwich ELISA. Blood pressure, blood lipid and renal function were measured. The differences between the two groups were compared. Multiple stepwise regression analysis of factors affecting KL level. Results The level of KL in T2DM group was lower than that in NC group [(4.9 ± 0.5) vs (5.4 ± 0.6) ng / ml, P <0.01]. There was still significant difference in KL between the two groups after covariance analysis (P <0.01). ISI and serum creatinine (Scr) are independent correlates of KL levels. Conclusions The level of plasma KL in T2DM patients is lower than that of ISI. KL may be a monitoring index to reflect the occurrence of IR and T2DM in patients.