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选择了小白鼠盲肠结扎穿孔所致感染性休克的实验模型，探索中医药开闭法（代表药７１７复方制剂）抗感染性休克的作用机制。结果：７１７复方制剂组小白鼠盲肠结扎穿孔术后的存活时间为２８．７５±５．０６小时，明显长于对照组（饮用水组）１２．５５±０．６３小时（Ｐ＜０．０５）；心脏组织匀浆中丙二醛（ＭＤＡ）为２３９．６２±１２．４１ｎｍｏｌ／ｍｇｐｒｏ，低于对照组２９７．８８±１７．０１ｎｍｏｌ／ｍｇｐｒｏ（Ｐ＜０．０５）；肝脏组织匀浆中ＭＤＡ为２７２．４１±５．９２ｎｍｏｌ／ｍｇｐｒｏ，明显低于对照组４２８．７７±１５．１４ｎｍｏｌ／ｍｇｐｒｏ，（Ｐ＜０．０１）。说明７１７复方制剂是通过抗氧化而起保护作用的。
The experimental model of septic shock induced by cecal ligation and puncture in mice was selected to explore the mechanism of anti-septic shock induced by the opening and closing method of Chinese medicine (representative medicine 717). Results: The survival time of the 717 compound preparation group after cecum ligation and perforation was 28.75 ± 5.06 hours, significantly longer than that of the control group (drinking water group) 12.55 ± 0.63 hours (P0.05) ; Malondialdehyde (MDA) in heart homogenate was 239.62 ± 12.41nmol / mgpro, which was lower than that in control group (297.88 ± 17.01nmol / mgpro, P <0.05) Was 272.41 ± 5.92nmol / mgpro, which was significantly lower than 428.77 ± 15.14nmol / mgpro in control group (P <0.01). Description 717 Compound is protected by antioxidants.