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头颈部鳞癌(squamous cell carcinoma of headand neck,SCCHN)是较常见的恶性肿瘤,其治疗效果曾长期存在若干瓶颈亟待突破。局部进展期SCCHN的治疗以手术及化放疗(chemoradiotheraphy,CRT)的综合治疗为主,虽可改善局部进展期SCCHN的控制率,但复发率、转移率却没有明显地降低,急性和远期的治疗毒性及其导致的器官功能损害仍不容忽视。对于复发转移性SCCHN,铂类单药
Squamous cell carcinoma of head and neck (SCCHN) is a more common malignant tumor. Its treatment effect has long been a bottleneck that needs to be overcome urgently. The treatment of locally advanced SCCHN with surgery and chemoradiotherapy (chemoradiotheraphy, CRT) the main treatment, although can improve the control rate of SCCHN, but the recurrence rate, metastasis rate was not significantly reduced, acute and long-term Therapeutic toxicity and its resulting organ dysfunction can not be ignored. For recurrent metastatic SCCHN, platinum monotherapy