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目的了解神经系统副肿瘤综合征患者的临床特点。方法收集我院收治的神经系统副肿瘤综合征患者28例,对其临床资料进行回顾性分析。结果患者多为慢性隐袭或亚急性起病,进行性加重,治疗后无明显缓解,3.8%患者在发现肿瘤后才出现神经症状;96.2%在出现副肿瘤症状后才发现肿瘤,副肿瘤综合征的临床类型有Lambert-Eaton肌无力综合征8例、周围神经病7例、多发性肌炎和皮肌炎4例、脑干脑炎3例、进行性小脑变性2例、边缘系统脑炎2例、运动神经元病1例、进行性多灶性白质脑病1例。结论神经系统副肿瘤综合征临床表现形式多样,容易误诊,临床早期确诊对于隐匿肿瘤的发现和治疗非常重要。
Objective To understand the clinical features of patients with neurological paraneoplastic syndromes. Methods Twenty-eight patients with paraneoplastic syndromes of the nervous system admitted to our hospital were collected. The clinical data were retrospectively analyzed. Results Most of the patients were chronic insidious or subacute onset with progressive exacerbations, with no significant relief after treatment. Neurological symptoms were found in 3.8% of the patients only after the tumor was found. 96.2% of the patients showed no tumor after the appearance of the accessory tumor, There were 8 cases of Lambert-Eaton myasthenic syndrome, 7 cases of peripheral neuropathy, 4 cases of polymyositis and dermatomyositis, 3 cases of brainstem encephalitis, 2 cases of progressive cerebellar degeneration, 2 cases of limbic system encephalitis Cases, motor neuron disease in 1 case, progressive multifocal leukoencephalopathy in 1 case. Conclusions The clinical manifestations of paraneoplastic syndromes of the nervous system are diverse and easily misdiagnosed. Early clinical diagnosis is very important for the discovery and treatment of occult tumors.