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Wnt信号通路在胚胎发育和肿瘤的发生过程中起着重要作用[1,2],近年研究发现该通路的异常与肥胖、胰岛素抵抗(insulin resistance,IR)和2型糖尿病(type 2 dia-betes mellitus,T2DM)的发生也密切相关。有研究表明该信号通路的激活可以抑制机体脂肪细胞的增生,并能调节胰岛β细胞的形态和功能[3]。还有研究报道Wnt通路
The Wnt signaling pathway plays an important role in embryonic development and tumorigenesis [1,2]. Recent studies have found that the abnormalities of this pathway are associated with obesity, insulin resistance (IR) and type 2 dia-betes mellitus, T2DM) are also closely related. Studies have shown that the activation of the signal pathway can inhibit the proliferation of body fat cells, and regulate the morphology and function of islet β cells [3]. There are also reports on the Wnt pathway