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硫酸庆大霉素的听神经和肾毒性是众所周知的。其毒性的大小与它的血药浓度有直接关系,血药浓度的高低决定於给药方案。文献报道,庆大霉素在(?)体内,其最低有效浓度为2μg/ml,最高治疗浓度(即最低中毒浓度)为12μg/ml,最佳治疗浓度范围为4—8μg/ml。但血药浓度长期高於2μg/ml 也会引起中毒。一般认为一次给药后,细菌经过一次冲击,血药浓度低於2μg/ml 的时间不超过4小时,由於杀菌剂的后遗作用,并不影响治疗效果,却能降低其毒性,因低的血药浓度有利於积累在听神
The auditory nerve and nephrotoxicity of gentamicin sulfate is well known. The size of its toxicity and its plasma concentration has a direct relationship between the level of plasma concentration depends on the drug program. Reported in the literature, gentamicin (?) In vivo, the minimum effective concentration of 2μg / ml, the highest treatment concentration (the lowest toxic concentration) of 12μg / ml, the best treatment concentration range of 4-8μg / ml. But long-term plasma concentrations higher than 2μg / ml can cause poisoning. It is generally considered that after one administration, the bacterium undergoes an impact and the blood concentration is less than 2 μg / ml for no more than 4 hours. As the germ-killing agent does not affect the therapeutic effect, it can reduce its toxicity. The low Blood concentration is conducive to accumulation in listening to God