论文部分内容阅读
目的探讨原发性中枢神经系统恶性淋巴瘤(PCNSL)的临床特征及诊疗经验。方法回顾性分析13例确诊为PCNSL患者的临床资料。结果 11例经立体定向穿刺活检,2例经手术切除病理确诊。术后均接受放疗和化疗。随访3例分别死于确诊后3月、11月、18月,2例存活已超过3年,2例已超过2年,2例已超过1年,确诊不到1年的4例生存良好。结论对影像学高度怀疑PCNSL的病人主张选择立体定向穿刺活检确诊,对有脑疝倾向或脑疝的病人仍需要开颅手术切除肿瘤。确诊后,以小剂量放疗+化疗的综合治疗疗效较好。
Objective To investigate the clinical features and diagnosis and treatment of primary central nervous system malignant lymphoma (PCNSL). Methods The clinical data of 13 patients diagnosed as PCNSL were retrospectively analyzed. Results of 11 cases by stereotactic biopsy, 2 cases were confirmed by surgical excision. All patients underwent radiotherapy and chemotherapy. Three patients died after the diagnosis in March, November and 18 months respectively. Two of them survived more than 3 years, 2 had been over 2 years, 2 had been over 1 year, and 4 cases survived less than 1 year after diagnosis. Conclusions The patients with high suspicion of PCNSL imaging were diagnosed by stereotactic biopsy, and the patients who had cerebral hernia tendency or hernia were still required to undergo craniotomy to remove the tumor. After diagnosis, a small dose of radiotherapy + chemotherapy combined treatment is better.