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采用原子吸收光谱法对饮用含氟、硒及氟和硒的去离子水溶液达八周的大鼠血清、心、肝、脾、肾组织中的铜、锌、铁含量进行了测定，以观察氟及氟硒联合作用对大鼠体内这些微量元素的影响。本研究结果表明，氟化物可引起大鼠血清铜、铁含量增高，心、肝、脾、肾组织中锌、铁含量增高，而使肾组织铜含量降低。氟硒联合作用可使大鼠血清铜明显降低，锌、铁含量明显增高，心、肝、脾、肾组织中铜、锌、铁含量增高。硒对氟致血清铜升高、肾铜降低具有明显拮抗作用，而对血清及心、肝、脾、肾组织中的锌、铁含量升高则具有显著的协同作用。
The contents of copper, zinc, and iron in serum, heart, liver, spleen and kidney of rats drinking fluoride, selenium, fluoride and selenium in deionized water for eight weeks were determined by atomic absorption spectrometry And fluorine and selenium on the impact of these trace elements in rats. The results of this study show that fluoride can cause serum copper and iron content increased, heart, liver, spleen and kidney tissue zinc, iron increased, leaving the renal tissue copper content decreased. The combined effect of fluorine and selenium can significantly reduce serum copper, zinc, iron content was significantly increased heart, liver, spleen and kidney tissue copper, zinc and iron content increased. Selenium has a significant antagonistic effect on the increase of serum copper and the decrease of renal copper in patients with fluoride, but has a significant synergistic effect on the serum and the contents of zinc and iron in heart, liver, spleen and kidney.